Low-dose apomorphine challenge in tardive akathisia.

Author(s): Sachdev P, Loneragan C

Affiliation(s): Neuropsychiatric Institute, Prince Henry Hospital, Sydney, Australia.

Publication date & source: 1993-03, Neurology., 43(3 Pt 1):544-7.

Publication type: Clinical Trial; Randomized Controlled Trial

We challenged seven tardive akathisia patients with low-dose apomorphine (0.01 mg/kg) SC and placebo in a double-blind, random design. Apomorphine caused a significantly greater reduction in the objective (movement) but not the subjective (distress) component of akathisia.