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Lack of anti-D in women at birth following antepartum immune globulin prophylaxis.

Author(s): Rudensky B, Mazaki E, Na'amad M, Samueloff A

Affiliation(s): Laboratory of Immunohaematology, Shaare Zedek Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er Sheva, Jerusalem 91031, Israel. rudensky@szm.org.il

Publication date & source: 2003-03-26, Eur J Obstet Gynecol Reprod Biol., 107(1):45-6.

Antepartum prophylaxis using Rh immune globulin suppresses maternal immunization to transplacental transfer of Rh-positive fetal cells, and, theoretically, to be effective, anti-D should be detectable until birth. We used a sensitive gel technique to quantitatively detect the serum concentration of anti-D at birth in 150 women who had received 300 microg of Rh immune globulin at 28 weeks gestation. Our method, which was sensitive enough to detect 20-25 microg, the recommended residual amount at birth, was positive in only 21% total, and in only 13% of women at term. Fifty-seven percent of women with premature births had above the recommended level of anti-D.

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