Use of fibrin sealants in cardiovascular surgery: a systematic review.
Author(s): Rousou JA.
Affiliation(s): Author information:
Division of Cardiac Surgery, Baystate Medical Center, Springfield, Massachusetts
01107, USA. jrousou@comcast.net
Publication date & source: 2013, J Card Surg. , 28(3):238-47
BACKGROUND: Fibrin sealants are used for hemostasis and tissue adherence.
AIM OF STUDY: This systematic review summarizes published clinical data for
fibrin sealant use in cardiovascular surgery.
METHODS: A literature search for the following terms was conducted using PubMed
and EMBASE: (TISSEEL or Tissucol or Beriplast P or Evicel or Quixil or Crosseal
or Reliseal or Fibringluraas or Bolheal or Tachosil or Vivostat or Vitagel or
Artiss or "fibrin glue" or "fibrin sealant" or "fibrin tissue adhesive") and
(cardiac or cardiovascular or vascular or heart or coronary or surgery). Case
reports and series were excluded; although reports of controlled trials were
preferred, uncontrolled trial data were also considered.
RESULTS: Clinical trials and chart review analyses of fibrin sealants were
identified and summarized. Although clinical trial data were available for other
agents, the majority of published studies examined TISSEEL. Overall, TISSEEL and
other fibrin sealants showed improvements over standard of care or control groups
for a variety of predefined endpoints. Safety findings are also summarized.
CONCLUSIONS: Data from these studies showed that fibrin sealants were well
tolerated and provided effective hemostasis in a range of cardiac and aortic
surgeries.
|