The effect of pregabalin on pain-related sleep interference in diabetic
peripheral neuropathy or postherpetic neuralgia: a review of nine clinical
Author(s): Roth T, van Seventer R, Murphy TK.
Affiliation(s): Division of Sleep Medicine and Research Center, Henry Ford Health System,
Detroit, MI 48202, USA. email@example.com
Publication date & source: 2010, Curr Med Res Opin. , 26(10):2411-9
OBJECTIVE: Postherpetic neuralgia and painful diabetic peripheral neuropathy are
common chronic neuropathic pain conditions associated with sleep disturbances.
Pregabalin is indicated in the treatment of neuropathic pain. The objective of
this review is to summarize the efficacy and safety of pregabalin in painful
diabetic peripheral neuropathy and postherpetic neuralgia and the effect of
pregabalin on sleep interference in these patients.
METHODS: MEDLINE and ISI Web of Knowledge databases were searched for randomized
double-blind, placebo-controlled clinical trials of pregabalin reporting sleep
measures in addition to pain endpoints in patients with painful diabetic
peripheral neuropathy and postherpetic neuralgia published from inception through
RESULTS: Nine trials met the inclusion criteria, providing data for a total of
2399 patients with painful diabetic peripheral neuropathy or postherpetic
neuralgia treated twice or three times per day with pregabalin (75-600 mg/day) or
placebo on a fixed or flexible schedule. Interpretation of sleep outcomes in two
studies may be limited by trial inclusion criteria which permitted
benzodiazepines for sleep problems. Also, none of the studies reported objective
sleep measures. Pregabalin was well tolerated. Pregabalin (150-600 mg/day)
significantly reduced pain and improved pain-related sleep interference.
CONCLUSIONS: In addition to an analgesic benefit, pregabalin may decrease
pain-related sleep interference in patients with painful diabetic peripheral
neuropathy and postherpetic neuralgia.