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Signs and symptoms of ocular surface status in glaucoma patients switched from timolol 0.5% to brinzolamide 1%/timolol 0.5% fixed combination: a 6-month efficacy and tolerability, multicenter, open-label prospective study.

Author(s): Rossi GC, Tinelli C, Pasinetti GM, Fusetti M, Pallavicini C, Stringa M, Vacchi S, Stringa F, Bianchi PE

Affiliation(s): University Eye Clinic of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia, Italy. gemma.rossi.md@gmail.com

Publication date & source: 2011-04, Expert Opin Pharmacother., 12(5):685-90. Epub 2011 Mar 9.

Publication type: Multicenter Study

PURPOSE: To examine the impact of switching glaucoma patients from timolol 0.5% to brinzolamide 1%/timolol 0.5% fixed combination (Brinz/Tim FC) on quality of life and on ocular surface status; to assess efficacy after the switch. METHODS: 6-month, multicenter, open-label, prospective, switch study in 119 early to moderate glaucoma patients. Intraocular pressure (IOP), tear film break-up time (TF-BUT), fluorescein staining and Glaucoma Symptom Scale (GSS) questionnaire were recorded at baseline and after 6 months. RESULTS: Median (interquartile range) IOP significantly decreased from 20 to 16 mmHg, independent of sex and age. Most patients (95.8%) reached an IOP < 18 mmHg. TF-BUT improved, with a negative weak correlation to age at baseline and at 6 months. The percentage of patients with no fluorescein staining improved. The quality of life recorded by GSS also improved, being related both to age and corneal staining. CONCLUSION: Brinz/Tim FC is effective and well tolerated. In this study, patients switched to Brinz/Tim FC obtained further reduction in IOP with no effects on ocular surface status and improved quality of life perception: a better quality of life could determine a better adherence to prescribed therapy.

Page last updated: 2011-12-09

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