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Effectiveness of diclofenac eyedrops in reducing inflammation and the incidence of cystoid macular edema after cataract surgery.

Author(s): Rossetti L, Bujtar E, Castoldi D, Torrazza C, Orzalesi N

Affiliation(s): Clinica Oculistica Universita di Milano, Istituto di Scienze Biomediche, Ospedale San Paolo, Milano, Italy.

Publication date & source: 1996, J Cataract Refract Surg., 22 Suppl 1:794-9.

Publication type: Clinical Trial; Randomized Controlled Trial

PURPOSE: To evaluate the effectiveness of diclofenac eyedrops in reducing inflammation and the incidence of angiographic cystoid macular edema (CME) after cataract surgery and intraocular lens (IOL) implantation. SETTING: Eye Clinic, Institute of Biomedical Sciences, San Paolo Hospital, Milan, Italy. METHODS: Eighty-eight patients having cataract extraction were enrolled in a randomized clinical trial: 42 were given diclofenac eyedrops and 46, placebo. Postoperative inflammation in both groups was graded for 6 months using a dedicated system. RESULTS: Eight patients (9%) had evidence of angiographic CME approximately 1 month after surgery: seven of these were in the placebo group (P = .039). This difference was not significant 3 and 6 months postoperatively. The signs of ocular inflammation were greater in the eyes receiving placebo; the difference was particularly evident up to 1 week after surgery. There was no significant difference in visual acuity between the two groups at any follow-up point, but the contrast sensitivity of the eyes that received diclofenac improved significantly at 10.5 cycles per degree 1 month postoperatively. CONCLUSION: Diclofenac eyedrops effectively reduced ocular inflammation and the occurrence of angiographic CME after cataract surgery.

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