Comparison of once-daily versus twice-daily administration of cefdinir against typical bacterial respiratory tract pathogens.
Author(s): Ross GH, Hovde LB, Ibrahim KH, Ibrahim YH, Rotschafer JC
Affiliation(s): College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Publication date & source: 2001-10, Antimicrob Agents Chemother., 45(10):2936-8.
In an in vitro pharmacodynamic model, a twice-daily cefdinir dosing regimen was more effective than a once-daily regimen against common bacterial respiratory pathogens in producing 3-log(10) killing and preventing the occurrence of regrowth at 24 h. Twice-daily administration is likely the more appropriate cefdinir dosing strategy for the treatment of community-acquired pneumonia.