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Design of an in-dwelling cannula for convection-enhanced delivery.

Author(s): Rosenbluth KH, Luz M, Mohr E, Mittermeyer S, Bringas J, Bankiewicz KS

Affiliation(s): Department of Neurosurgery, University of California San Francisco, 1855 Folsom St, MCB226, San Francisco, CA 94103-0555, USA.

Publication date & source: 2011-03-15, J Neurosci Methods., 196(1):118-23. Epub 2010 Dec 25.

Publication type: Research Support, N.I.H., Extramural

Failures of recent convection-enhanced delivery (CED) trials have underscored the need for improved CED cannulae. This study presents a novel in-dwelling cannula targeted for use in upcoming neuro-oncological or neurodegeneration trials. The cannula is reflux-resistant and easily integrated into clinical workflows. The cannula was evaluated in non-human primate CED studies performed with magnetic resonance imaging (MRI) to validate the effectiveness and safety of the infusion. Copyright (c) 2011. Published by Elsevier B.V.

Page last updated: 2011-12-09

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