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Patients' preference of valacyclovir once-daily suppressive therapy versus twice-daily episodic therapy for recurrent genital herpes: a randomized study.

Author(s): Romanowski B, Marina RB, Roberts JN, Valtrex HS230017 Study Group

Affiliation(s): University of Alberta, Edmonton, Alberta, Canada. broman@docromanowski.com

Publication date & source: 2003-03, Sex Transm Dis., 30(3):226-31.

Publication type: Clinical Trial; Comment; Multicenter Study; Randomized Controlled Trial

BACKGROUND: Valacyclovir is effective for suppressive and episodic treatment of recurrent genital herpes. Few data on patients' treatment strategy preferences are available. GOAL: The goal was to assess patients' preference, satisfaction, and quality of life with suppressive versus episodic treatment of recurrent genital herpes. STUDY DESIGN: This was a multicenter, open-label, randomized, two-arm, crossover 48-week study involving 225 patients with genital herpes. RESULTS: Suppressive valacyclovir therapy was preferred to episodic valacyclovir treatment by 72% of patients (P < 0.001). Overall treatment satisfaction and quality of life were significantly greater during suppressive therapy (P < 0.001 and P = 0.002, respectively). The risk of recurrence during the first 24 weeks was reduced by 78% with suppressive therapy (P < 0.001). Significantly fewer patients experienced recurrences during suppressive treatment than with episodic treatment (P < 0.001). Valacyclovir was well tolerated. CONCLUSIONS: Suppressive valacyclovir was preferred to episodic therapy by most patients. Suppressive therapy was associated with increased treatment satisfaction, and decreased risk and lower frequency of recurrences.

Page last updated: 2006-01-31

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