Posaconazole combined with amphotericin B, an effective therapy for a murine disseminated infection caused by Rhizopus oryzae.

Author(s): Rodriguez MM, Serena C, Marine M, Pastor FJ, Guarro J

Affiliation(s): Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Spain.

Publication date & source: 2008-10, Antimicrob Agents Chemother., 52(10):3786-8. Epub 2008 Aug 11.

Publication type: Research Support, Non-U.S. Gov't

In a murine model of disseminated zygomycosis, low doses of amphotericin B (0.3 mg/kg body weight/day) combined with posaconazole (40 mg/kg/day) prolonged survival and reduced tissue burden with respect to that of controls and that of both drugs administered alone. Results were similar to those obtained with amphotericin B given alone at 0.8 mg/kg/day.