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Severe exacerbation of multiple self-healing squamous epithelioma (Ferguson-Smith disease) with radiotherapy, which was successfully treated with acitretin.

Author(s): Robertson SJ, Bashir SJ, Pichert G, Robson A, Whittaker S

Affiliation(s): St John's Institute of Dermatology, Guy's and St Thomas' NHS Trust, London, UK. drsjrobertson@gmail.com

Publication date & source: 2010-06, Clin Exp Dermatol., 35(4):e100-2. Epub 2009 Oct 23.

Publication type: Case Reports

We describe the challenging case of a patient presenting with extensive, eruptive mid-facial squamous cell carcinomas (SCCs) and keratoacanthomas (KAs) consequent to radiotherapy. Our patient had a personal and family history of multiple KAs and SCCs. Multiple self-healing squamous epithelioma, otherwise known as Ferguson-Smith disease, was diagnosed. This case presented a therapeutic challenge to preserve tissue and avoid severe facial disfigurement. We found oral acitretin to be the treatment of choice.

Page last updated: 2011-12-09

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