Relative bioavailability of three newly developed albendazole formulations: a randomized crossover study with healthy volunteers.

Author(s): Rigter IM, Schipper HG, Koopmans RP, van Kan HJ, Frijlink HW, Kager PA, Guchelaar HJ

Affiliation(s): Department of Clinical Pharmacy, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Publication date & source: 2004-03, Antimicrob Agents Chemother., 48(3):1051-4.

Publication type: Clinical Trial; Randomized Controlled Trial

This study of healthy volunteers shows that the relative bioavailability of albendazole formulations that use arachis oil-polysorbate 80 or hydroxypropyl-beta-cyclodextrin as an excipient was enhanced 4.3- and 9.7-fold compared to the results seen with commercial tablets. Administration of macrogol suppositories did not result in measurable plasma concentrations of albendazole sulfoxide.