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Depressive symptoms and their association with acute treatment outcome in first-episode schizophrenia patients: Comparing treatment with risperidone and haloperidol.

Author(s): Riedel M, Mayr A, Seemuller F, Maier W, Klingberg S, Heuser I, Klosterkotter J, Gastpar M, Schmitt A, Sauer H, Schneider F, Gaebel W, Jager M, Moller HJ, Schennach-Wolff R

Affiliation(s): Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.

Publication date & source: 2011-05-13, World J Biol Psychiatry., [Epub ahead of print]

Abstract Objective. To evaluate depressive symptoms regarding their association with the acute outcome in first-episode schizophrenia comparing risperidone and haloperidol. Method. A total of 274 patients were analysed within a double-blind randomized controlled trial and treated with risperidone or haloperidol. The patients were grouped according to their baseline HAMD-21 total score in a "depressed" (HAMD-21 >/=16) or "non-depressed" (HAMD-21 <16) patient subgroup. PANSS, HAMD-21, GAF, SOFAS and AIMS ratings were performed. Early response was defined as an initial 20% reduction of the PANSS total score from admission to week 2, response as an at least 50% reduction of the PANSS total score from admission to discharge and remission according to the consensus criteria. Results. A total of 124 patients were classified as depressive at baseline with 22 patients still being depressive at discharge. The depressed and non-depressed patients did not significantly differ regarding the treatment with risperidone and haloperidol (P = 0.2270). The depressive patients suffered from significantly more suicidal tendencies (P = 0.0165), had significantly less insight into their illness (P = 0.0152) and featured significantly worse functioning (P = 0.0066). Patients with depressive symptoms achieved remission significantly less often than non-depressed patients. Conclusion. The importance of a specific and adequate treatment of depressive symptoms is highlighted.

Page last updated: 2011-12-09

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