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A vascular effect of IgG therapy may prevent transplacental red cell leakage and spontaneous thrombocytopenic haemorrhages.

Author(s): Rewald E

Affiliation(s): Fundacion Hematologica, Mar del Plata, Argentina.

Publication date & source: 1990-11, Med Hypotheses., 33(3):193-5.

Publication type: Case Reports

It is postulated that intravenous immunoglobin therapy may improve the red cell barrier of placenta and of capillary endothelia; the former protecting against anti-Rh antibody booster reaction and the latter preventing spontaneous thrombocytopenic bleedings. The effect on permeability may also reduce the passage of anti-Rh antibodies to the foetus.

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