A vascular effect of IgG therapy may prevent transplacental red cell leakage and spontaneous thrombocytopenic haemorrhages.
Author(s): Rewald E
Affiliation(s): Fundacion Hematologica, Mar del Plata, Argentina.
Publication date & source: 1990-11, Med Hypotheses., 33(3):193-5.
Publication type: Case Reports
It is postulated that intravenous immunoglobin therapy may improve the red cell barrier of placenta and of capillary endothelia; the former protecting against anti-Rh antibody booster reaction and the latter preventing spontaneous thrombocytopenic bleedings. The effect on permeability may also reduce the passage of anti-Rh antibodies to the foetus.