A high-throughput approach towards a novel formulation of fenofibrate in omega-3 oil.

Author(s): Ratanabanangkoon P, Guzman H, Almarsson O, Berkovitz D, Tokarcyzk S, Straughn AB, Chen H

Affiliation(s): TransForm Pharmaceuticals, Inc., 29 Hartwell Avenue, Lexington, MA 02421, United States.

Publication date & source: 2008-04-23, Eur J Pharm Sci., 33(4-5):351-60. Epub 2008 Jan 21.

Publication type: Randomized Controlled Trial

A novel lipid formulation containing fenofibrate in omega-3 oil was developed using a novel high-throughput screening platform. The optimized formulation combines the cardiovascular health benefits from omega-3 oil with the potent lipid-regulating effect of fenofibrate. When tested against the current marketed product Tricor in healthy human volunteers, the new formulation was shown to be equivalent to Tricor.