Seizure length with sevoflurane and thiopental for induction of general anesthesia in electroconvulsive therapy: a randomized double-blind trial.

Author(s): Rasmussen KG, Laurila DR, Brady BM, Lewis CL, Niemeyer KD, Sun NM, Marienau ME, Hooten WM, Schroeder DR, Spackman TM

Affiliation(s): Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA. rasmussen.keith@mayo.edu

Publication date & source: 2006-12, J ECT., 22(4):240-2.

Publication type: Randomized Controlled Trial

In general, seizure length does not correlate with clinical outcome with electroconvulsive therapy (ECT), but whether markedly short seizures are still therapeutic is unknown. Furthermore, seizure length effects on clinical outcome in ECT may be different among the various anesthetic agents available. Several studies have investigated the use of inhalational anesthesia in ECT with sevoflurane. In general, seizure length when reported has been in the range of typical values encountered in practice. We recently completed a randomized double blind trial with sevoflurane induction compared with thiopental. Seizure duration with sevoflurane anesthesia was 8 seconds shorter than with thiopental for electroencephalogram and 6.4 seconds shorter for motor, the latter just barely missing statistical significance. Absolute values for seizure duration with both sevoflurane and thiopental are well within typical ranges for those seen with the more commonly used methohexital as anesthetic.