Stereotypy II: a review of neurobiological interpretations and suggestions for an integration with behavioral methods.

Author(s): Rapp JT, Vollmer TR

Affiliation(s): Texana MHMR, Behavior Treatment and Training Center, 1818 Collins Road, Richmond, TX 77469, USA. john.rapp@texanamhmr.com

Publication date & source: 2005-11, Res Dev Disabil., 26(6):548-64. Epub 2005 Jan 25.

Publication type: Research Support, N.I.H., Extramural ; Review

Stereotypy is a relatively common behavioral disorder displayed by individuals with developmental disabilities, including autism. In this paper, we review selected studies on neurobiological interpretations of stereotypy and pharmacological interventions for stereotypy. Specifically, we review studies that evaluated the effects of serotonin uptake inhibitors (e.g., clomipramine) or opioid antagonists (e.g., naltrexone) on stereotypy displayed by humans. Throughout, suggestions are made for the incorporation of behavioral methods into this area of research.