Mefloquine versus 3-day oral quinine-clindamycin in uncomplicated imported falciparum malaria.

Author(s): Ranque S, Parola P, Adehossi E, Brouqui P, Delmont J

Affiliation(s): Laboratoire de Parasitologie et Mycologie, IFR 48, Faculte de Medecine, 27 Bd. Jean Moulin, 13385 Marseille Cedex 5, France.

Publication date & source: 2007-09, Travel Med Infect Dis., 5(5):306-9. Epub 2007 Aug 20.

Publication type:

In this open randomized trial comparing 3-day oral quinine-clindamycin versus standard mefloquine regimen for uncomplicated imported falciparum malaria, mefloquine treatment was associated with a higher risk of discontinuation of the treatment (RR=1.8, 95% CI [1.1-2.8]) related to mainly mild gastrointestinal adverse drug events. The poor tolerability of mefloquine sets a question mark against its use in outpatients.