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The effect of triethanolamine application on anthralin-induced inflammation and therapeutic effect in psoriasis.

Author(s): Ramsay B, Lawrence CM, Bruce JM, Shuster S

Affiliation(s): Department of Dermatology, Royal Victoria Infirmary, Newcastle-upon-Tyne, U.K.

Publication date & source: 1990-07, J Am Acad Dermatol., 23(1):73-6.

Publication type: Clinical Trial; Controlled Clinical Trial

Twenty patients with chronic plaque psoriasis were treated with short-contact anthralin followed by 10% triethanolamine application to one side of the body and aqueous cream to the other. Anthralin-induced inflammation was inhibited on the triethanolamine-treated side whereas anthralin therapy had to be temporarily stopped in 18 patients on the aqueous cream side because of anthralin-induced inflammation. Therapeutic response was not different in the two sides. This study shows that anthralin-induced inflammation and its therapeutic effect can be dissociated.

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