The effect of four-week administration of amitriptyline on sleep bruxism. A double-blind crossover clinical study.

Author(s): Raigrodski AJ, Christensen LV, Mohamed SE, Gardiner DM

Affiliation(s): Department of Prosthodontics at the Louisiana State University Health Sciences Center, School of Dentistry, New Orleans 70119-2799, USA.

Publication date & source: 2001-01, Cranio., 19(1):21-5.

Publication type: Clinical Trial; Randomized Controlled Trial

The purpose of this study was to evaluate the effect of a tricyclic antidepressant (amitriptyline) on nocturnal masseteric activity and duration of sleep in bruxists. Using a randomized, double blind, crossover design, ten females (mean age 39 yrs, +/- sd seven yrs) received active (amitriptyline 25 mg/night) and inactive (placebo 25 mg/night) medication, over a period of four weeks each. A portable EMG integrator recorded the nocturnal, unilateral, and cumulative myoelectrical activity (microV/min of sleep) of the masseter muscle during the fourth and eighth weeks of the study. The results showed that amitriptyline did not significantly decrease the mean EMG activity (df = 9, alpha = 0.05, paired-t = 0.892, p = 0.3964), nor did it significantly increase the duration of sleep (df = 9, alpha = 0.05, paired-t = 2.140, p = 0.061). The results of this study do not support the administration of 25 mg of amitriptyline per night over a period of four weeks for the management of sleep bruxism.