Effect of Fenugreek Seeds on Serum Metabolic Factors and Adiponectin Levels in
Type 2 Diabetic Patients.
Author(s): Rafraf M(1), Malekiyan M, Asghari-Jafarabadi M, Aliasgarzadeh A.
Affiliation(s): Author information:
(1)1 Nutrition Research Center, Department of Nutrition in Community, Faculty of
Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Publication date & source: 2014, Int J Vitam Nutr Res. , 84(3-4):196-205
This triple-blind randomized controlled clinical trial was conducted on 88 type 2
diabetic (T2DM) patients (males and females). Subjects in the fenugreek seed
(n=44) and placebo (n=44) groups consumed 10 g/d of powdered whole fenugreek
seeds or 5 g/d of wheat starch for 8 weeks. Fasting blood samples, anthropometric
measurements and dietary records were collected at the baseline and at the end of
the trial. Fenugreek seeds significantly decreased fasting blood glucose
(P=0.007) and HbA1c (P=0.0001), serum levels of insulin (P=0.03), homeostatic
model assessment for insulin resistance (P=0.004), total cholesterol (P=0.005)
and triglycerides (P=0.0001) and increased serum levels of adiponectin (P=0.001)
compared with placebo. No significant changes were shown in serum low-density
lipoprotein cholesterol and high-density lipoprotein cholesterol in both groups.
In conclusion, fenugreek seeds improved glucose metabolism, serum lipid profile
and adiponectin levels in studied subjects, and may be useful in the control of
diabetes risk factors in TD2M patients.
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