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Nilotinib.

Author(s): Quintas-Cardama A, Kim TD, Cataldo V, le Coutre P

Affiliation(s): Medizinische Klinik m.S Hamatologie und Onkologie, Charite-Universitatsmedizin Berlin, Germany. Philipp.lecoutre@charite.de

Publication date & source: 2010, Recent Results Cancer Res., 184:103-17.

Publication type: Review

Therapy with imatinib mesylate is a standard of care for most patients with Philadelphia chromosome-positive chronic myeloid leukemia (CML). However, resistance or intolerance to imatinib develops in a considerable number of patients leading to relapse or discontinuation of treatment. Nilotinib is a rationally designed second-generation tyrosine kinase inhibitor (TKI) with improved affinity and specificity against the BCR-ABL kinase, when compared with imatinib. Considerable efficacy after imatinib failure has been demonstrated in clinical trials leading to nilotinib's current approval as second-line therapy for CML in chronic and accelerated phase (AP). The role of nilotinib as first-line treatment for CML, in combinatorial strategies and in the context of specific BCR-ABL mutations, requires future studies.

Page last updated: 2010-10-05

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