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The successful treatment of a gender dysphoric patient with pimozide.

Author(s): Puri BK, Singh I

Affiliation(s): Department of Psychiatry, Charing Cross and Westminster Medical School, University of London, UK.

Publication date & source: 1996-06, Aust N Z J Psychiatry., 30(3):422-5.

Publication type: Case Reports

OBJECTIVE: The case is reported of a gender dysphoric patient who responded successfully to pharmacotherapy with pimozide. CLINICAL PICTURE: An adult male patient with a borderline learning disability presented with cross-dressing and a strong wish to undergo a sex change. TREATMENT: Supportive psychotherapy and pharmacotherapy with pimozide was tried. OUTCOME: There was an excellent response to pimozide 2 mg daily, with a cessation of both cross-dressing and the wish for sex reassignment. When, after 1 year, the dose was reduced to 1 mg daily, there was a rapid return of the cross-dressing and the wish for sex reassignment. An increase in the dose again led to a remission which has been maintained since then. CONCLUSION: Pharmacotherapy with pimozide should be considered in cases of doubtful gender dysphoria.

Page last updated: 2006-01-31

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