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Pseudoscleroderma secondary to phytonadione (vitamin K1) injections.

Author(s): Pujol RM, Puig L, Moreno A, Perez M, de Moragas JM

Affiliation(s): Department of Dermatology, Hospital de Sant Pau, Barcelona, Spain.

Publication date & source: 1989-04, Cutis., 43(4):365-8.

Publication type: Case Reports

Two patients showed symmetrical sclerodermoid (morphea-like) skin lesions at sites of intramuscular phytonadione (vitamin K1) injections. The lesions appeared one and two years after the injections. A dense sclerosis involving the reticular dermis and subcutaneous fat was observed on histologic examination of biopsy specimens. Local adverse reactions to phytonadione are reviewed. Possible causative mechanisms for phytonadione-induced pseudoscleroderma are discussed.

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