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Penetration of topically administered ofloxacin and trimethoprim into aqueous humor.

Author(s): Price FW Jr, Dobbins K, Zeh W

Affiliation(s): Cornea Research Foundation, Indianapolis, Indiana, USA. fprice@pricevisiongroup.net

Publication date & source: 2002-10, J Ocul Pharmacol Ther., 18(5):445-53.

Publication type: Clinical Trial; Randomized Controlled Trial

Ocular penetration of two topical antibiotics used to treat bacterial conjunctivitis was assessed in adult volunteers scheduled for cataract surgery. In this randomized, parallel-group study, patients instilled trimethoprim sulfate 0.1%/polymyxin B (n = 23) or ofloxacin 0.3% (n = 25) QID for 3 days, plus 4 instillations in the hour before surgery. Analysis of aqueous humor samples obtained during surgery showed a 2.4-fold greater concentration of ofloxacin over trimethoprim (1.135 micro g/ml vs 0.470 micro g/ml; P <.0001). The greater concentration of ofloxacin in ocular tissue coupled with its superior antibacterial activity profile supports its use as an alternative to trimethoprim/polymyxin B for treatment of bacterial conjunctivitis.

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