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Local drug delivery of 0.5% azithromycin in the treatment of chronic periodontitis among smokers.

Author(s): Pradeep AR(1), Bajaj P, Agarwal E, Rao NS, Naik SB, Kalra N, Priyanka N.

Affiliation(s): Author information: (1)Department of Periodontics, Government Dental College and Research Institute, Bangalore, India. periodonticsgdcri@gmail.com

Publication date & source: 2013, Aust Dent J. , 58(1):34-40

BACKGROUND: Along with conventional periodontal surgical therapy, local delivery of antibiotics may provide more effective treatment in smokers by targeting tissue-invasive bacteria. The aim of this randomized, placebo-controlled, double-masked clinical trial was to evaluate the adjunctive effects of subgingivally delivered 0.5% azithromycin (AZM) as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis in smokers. METHODS: Fifty-four patients were randomized and categorized into two treatment groups: Group 1 - 26 subjects who received (SRP) plus placebo gel and Group 2 - 28 subjects who received (SRP) plus 0.5% azithromycin. Clinical parameters were recorded at baseline, 3, 6 and 9 months. They included Plaque Index (PI), modified Sulcus Bleeding Index (mSBI), probing depth (PD) and clinical attachment level (CAL). RESULTS: Azithromycin resulted in significant improvements. A single application of AZM resulted in attachment gain at 9 months of 2.44 ± 0.64 mm as compared to 0.18 ± 0.68 mm for the placebo. Similarly, pocket depth and PI were significantly reduced but no change in the mSBI was noted. CONCLUSIONS: When compared to the placebo, the adjunctive use of 0.5% AZM resulted in significant improvement in clinical outcome in the treatment of chronic periodontitis among smokers.

Erratum in Aust Dent J. 2013 Jun;58(2):272. Priyanaka, N [corrected to Priyanka, N].

Page last updated: 2014-11-30

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