Bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration: a double blind controlled study.

Author(s): Power WJ, Benedict-Smith A, Hillery M, Brady K, Collum LM

Affiliation(s): Royal Victoria Eye and Ear Hospital, Dublin, Ireland.

Publication date & source: 1991, Curr Eye Res., 10 Suppl:183-7.

Publication type: Clinical Trial; Comparative Study; Randomized Controlled Trial

Fifty patients with corneal dendritic ulceration were randomly entered into a double blind clinical trial comparing BVDU eyedrops with TFT eyedrops. Of those receiving TFT 100% healed in a mean time of 6.7 days, while 92% of those receiving BVDU healed in a mean time of 8.7 days. There was no statistical difference between the two groups in terms of numbers healed, but BVDU was significantly slower in terms of days to heal. After a mean follow-up period of 7.5 months there has been one recurrence in each group.