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Blood concentrations of clobazam and norclobazam in a lethal case involving clobazam, meprobamate and clorazepate.

Author(s): Pok PR, Mauras M, De Saint Leger MN, Kuhlmann E, Charpenel-Durat C, Navarette C, Duval ML, De Meo P

Affiliation(s): INPS, Laboratoire de Police Scientifique de Marseille, Section Toxicologie, 97, Boulevard Camille Flammarion, BP30, 13245 Marseille, Cedex 04, France. rop-pos.pok@interieur.gouv.fr

Publication date & source: 2010-11, Leg Med (Tokyo)., 12(6):300-4. Epub 2010 Sep 25.

Publication type: Case Reports

Clobazam is a benzodiazepine with anti-anxiety and anticonvulsant properties marketed in several countries. Norclobazam, a metabolite of clobazam, has similar pharmacological activity but weaker sedative and tranquilizing effect. The two drugs were detected by GC-MS and determined by HPLC-DAD in the samples from a postmortem case. The femoral blood concentrations of clobazam and norclobazam were 0.72 and 36 mug/mL, respectively. The concentration of the active norclobazam was very high. The sum of both clobazam and norclobazam blood concentration (36.72 mug/mL) was clearly toxic, but was not necessarily fatal. Other associated drugs concentrations were within their therapeutic ranges. Interactions due to drug association were discussed. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

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