Relation of dose of carvedilol to reduction in QT dispersion in patients with mild to moderate heart failure secondary to ischemic or to idiopathic dilated cardiomyopathy.

Author(s): Pittenger B, Gill EA, Holcslaw TL, Bristow MR

Affiliation(s): Department of Medicine, Division of Cardiology, University of Washington, Seattle 98195-9748, USA.

Publication date & source: 2004-12-01, Am J Cardiol., 94(11):1459-62.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

Carvedilol has been shown to improve survival and morbidity in patients with heart failure. It has been demonstrated that carvedilol use is associated with dose-dependent reduction in QT dispersion (QTd) independent of the cause of heart failure, suggesting that reduction in QTd may be a mechanism by which carvedilol improves outcomes in heart failure.