Randomized controlled single center study comparing a polyhexanide containing bio-cellulose dressing with silver sulfadiazine cream in partial-thickness dermal burns.
Author(s): Piatkowski A, Drummer N, Andriessen A, Ulrich D, Pallua N
Affiliation(s): Department of Plastic Surgery and Hand Surgery-Burn Unit, RWTH-University Hospital Aachen, Pauwelsstr. 30, 52057 Aachen, Germany. firstname.lastname@example.org
Publication date & source: 2011-08, Burns., 37(5):800-4. Epub 2011 Feb 23.
Publication type: Comparative Study; Randomized Controlled Trial
OBJECTIVE: A prospective, randomized, controlled single center study was designed to evaluate clinical efficacy of a polyhexanide containing bio-cellulose dressing (group B) compared to a silver-sulfadiazine cream (group A) in sixty partial-thickness burn patients. PATIENTS AND METHODS: Local ethics committee approval was obtained and patients consented. Parameters were: pain reduction (VAS), healing time and wound bed condition, comparing day 0 (start) versus day 14 (end), as well as, ease of dressing use and treatment costs. RESULTS: All completed the study (n=30/n=30) and were included in the ITT analysis, with a total of 72 burns (group A: n=38, group B: n=34). We noted no differences in healing time. Pain reduction was significantly faster and better in group B (p<0.01). There were fewer dressing changes in group B, compared to group A. Ease of use for the bio-cellulose dressing was rated better compared to group A. In group B, euro 95.20 was saved for a 10 day treatment period, compared to group A. CONCLUSION: Group B demonstrated a better and faster pain reduction in the treated partial-thickness burns, compared to group A. The results indicate the polyhexanide containing bio-cellulose dressing to be a safe and cost effective treatment for partial-thickness burns. Copyright (c) 2011 Elsevier Ltd and ISBI. All rights reserved.