Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitro.

Author(s): Perkhofer S, Locher M, Cuenca-Estrella M, Ruchel R, Wurzner R, Dierich MP, Lass-Florl C

Affiliation(s): Department of Hygiene, Microbiology and Social Medicine, Medical University Innsbruck, Fritz-Pregl Str. 3, A-6020 Innsbruck, Austria. Susanne.Perkhofer@i-med.ac.at

Publication date & source: 2008-07, Antimicrob Agents Chemother., 52(7):2636-8. Epub 2008 May 5.

Publication type:

The in vitro activity of posaconazole plus amphotericin B against conidia and hyphae of 30 clinical zygomycetes was investigated. The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P < 0.05) than against conidia (10%). Antagonism was not observed.