DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



A long-term study of photodynamic therapy with verteporfin for choroidal neovascularization at the edge of chorioretinal atrophy in pathologic myopia.

Author(s): Pece A, Milani P, Isola V, Pierro L

Affiliation(s): Department of Ophthalmology, Melegnano Hospital, Milan, Italy. pece.retina@mclink.it

Publication date & source: 2011, Ophthalmologica., 225(3):161-8. Epub 2011 Jan 5.

Publication type: Research Support, Non-U.S. Gov't

PURPOSE: To evaluate the effects of verteporfin photodynamic therapy (PDT) on choroidal neovascularization (CNV) at the edge of chorioretinal atrophy in eyes with pathologic myopia. PROCEDURES: Twenty eyes of 20 consecutive patients were treated according to Verteporfin in Photodynamic Therapy criteria. The patients were divided into 3 groups based on CNV location and were followed up with clinical and fluorescein angiographic examinations to evaluate visual acuity (VA) changes and number of treatments. RESULTS: The mean follow-up was 35 months. In group 1 (n = 8; subfoveal CNV), VA declined from 20/73 (0.56 +/- 0.26 logMAR) to 20/115 (0.76 +/- 0.30 logMAR; p = 0.192). In group 2 (n = 6; juxtafoveal CNV), VA improved from 20/69 (0.54 +/- 0.25 logMAR) to 20/46 (0.36 +/- 0.16 logMAR; p = 0.176). In group 3 (n = 6; extrafoveal CNV), VA worsened from 20/50 (0.40 +/- 0.21 logMAR) to 20/91 (0.66 +/- 0.49 logMAR; p = 0.292). CONCLUSIONS: PDT showed inhibitory effects on myopic CNV arising at the edge of chorioretinal atrophy, especially in young adult myopic eyes with juxtafoveal neovascular membranes. Copyright (c) 2011 S. Karger AG, Basel.

Page last updated: 2011-12-09

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017