Corticosteroid after etomidate in critically ill patients: A randomized controlled trial.
Author(s): Payen JF, Dupuis C, Trouve-Buisson T, Vinclair M, Broux C, Bouzat P, Genty C, Monneret D, Faure P, Chabre O, Bosson JL
Affiliation(s): From the Departments of Anesthesiology and Critical Care (J-FP, CD, TT-B, MV, CB, PB) and Endocrinology (OC) Albert Michallon Hospital, Grenoble, France; Grenoble Institut des Neurosciences and INSERM U836 (J-FP, PB), Joseph Fourier University, Grenoble, France; Clinical Research Center INSERM 003 (CG, J-LB), Michallon Hospital, and UJF-Grenoble 1, CNRS, TIMC-IMAG, UMR 5525, Grenoble, France; and the Department of Biochemistry (DM, PF), Albert Michallon Hospital, and Laboratoire HP2, INSERM U1042, Joseph Fourier University, Grenoble, France.
Publication date & source: 2011-09-15, Crit Care Med., [Epub ahead of print]
OBJECTIVE:: To investigate the effects of moderate-dose hydrocortisone on hemodynamic status in critically ill patients throughout the period of etomidate-related adrenal insufficiency. DESIGN:: Randomized, controlled, double-blind trial (NCT00862381). SETTING:: University hospital emergency department and three intensive care units. INTERVENTIONS:: After single-dose etomidate (H0) for facilitating endotracheal intubation, patients without septic shock were randomly allocated at H6 to receive a 42-hr continuous infusion of either hydrocortisone at 200 mg/day (HC group; n = 49) or saline serum (control group; n = 50). MEASUREMENTS AND MAIN RESULTS:: After completion of a corticotrophin stimulation test, serum cortisol and 11beta-deoxycortisol concentrations were subsequently assayed at H6, H12, H24, and H48. Forty-eight patients were analyzed in the HC group and 49 patients in the control group. Before treatment, the diagnostic criteria for etomidate-related adrenal insufficiency were fulfilled in 41 of 45 (91%) and 38 of 45 (84%) patients in the HC and control groups, respectively. The proportion of patients with a cardiovascular Sequential Organ Failure Assessment score of 3 or 4 declined comparably over time in both HC and control groups: 65% vs. 67% at H6, 65% vs. 69% at H12, 44% vs. 54% at H24, and 34% vs. 45% at H48, respectively. Required doses of norepinephrine decreased at a significantly higher rate in the HC group compared with the control group in patients treated with norepinephrine at H6. No intergroup differences were found regarding the duration of mechanical ventilation, intensive care unit length of stay, or 28-day mortality. CONCLUSION:: These findings suggest that critically ill patients without septic shock do not benefit from moderate-dose hydrocortisone administered to overcome etomidate-related adrenal insufficiency.