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Safety of a combination diphtheria, tetanus toxoid, acellular pertussis, hepatitis B, and inactivated polio vaccine coadministered with a 7-valent pneumococcal conjugate vaccine and a Haemophilus influenzae type b conjugate vaccine.

Author(s): Partridge S, Alvey J, Bernstein H, Blatter M, Bottenfield G, Guerrero J, Senders SD, Schuerman L, Cheuvart B, Holmes SJ

Affiliation(s): UCLA School of Medicine, 1124 W Carson Street, LIU Research Bldg, Torrance, CA 90502, United States.

Publication date & source: 2007-02-26, Vaccine., 25(10):1806-13. Epub 2006 Nov 21.

The safety of DTaP-HepB-IPV vaccine coadministered with PCV and Hib was compared with separate administration of DTaP, HepB, IPV, Hib, and PCV at 2, 4, and 6 months of age. Healthy 2-month-old infants (N=1008) were randomized to the two groups. Following dose 1, there was no significant difference between the groups in the incidence of fever >101.3 degrees F. After each dose, the incidence of any fever (>/=100.4 degrees F) was significantly higher in the Combination Vaccine Group. The rate of fever >103.1 degrees F was </=1.4% in both groups after any of the doses. Medical advice visits for fever were infrequent in both groups (</=1.2%). DTaP-HepB-IPV was safe and well tolerated when coadministered with PCV and Hib.

Page last updated: 2007-02-12

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