DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Compatibility of tacrolimus ointment with corticosteroid ointments of varying potencies.

Author(s): Pappas L, Kiss A, Levitt J

Affiliation(s): Wayne State School of Medicine, Detroit, MI, USA.

Publication date & source: 2009-05, J Cutan Med Surg., 13(3):140-5.

Publication type: Comparative Study; Research Support, Non-U.S. Gov't

BACKGROUND: Tacrolimus is often coadministered with various topical corticosteroids in the treatment of steroid-responsive dermatoses; however, the stability of these products in combination has not been examined extensively. OBJECTIVE: To assess the in vitro compatibility of three tacrolimus-corticosteroid ointment combinations compared with unmixed controls. METHODS: Tacrolimus-clobetasol propionate, tacrolimus-desoximetasone, and tacrolimus-hydrocortisone-17-valerate ointment combinations were prepared, stored with unmixed ointments at three temperature/humidity conditions, and evaluated for stability at days 0, 1, 2, 7, 14, and 28 via reverse-phase high-performance liquid chromatography. RESULTS: There was no significant difference in the rate of drug degradation in mixed and unmixed ointments over time or across temperatures for tacrolimus (time p = .94; temperature p = .44), clobetasol (time p = .98, temperature p = .30), desoximetasone (time p = .98; temperature p = .94), or hydrocortisone-17-valerate (time p = .87, temperature p = .36). LIMITATIONS: This study did not examine the compatibility of tacrolimus with nonointment formulations. CONCLUSION: Tacrolimus-clobetasol propionate (superpotent), tacrolimus-desoximetasone (high potent), and tacrolimus-hydrocortisone-17-valerate (midpotent) ointment combinations are chemically compatible for at least 4 weeks.

Page last updated: 2009-10-20

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017