Allopurinol mouth rinse for prophylaxis of fluorouracil-induced mucositis.
Author(s): Panahi Y, Ala S, Saeedi M, Okhovatian A, Bazzaz N, Naghizadeh MM.
Affiliation(s): Research Center of Chemical Injuries, Baqiyatallah University of Medical
Sciences, Tehran, Iran. yunespanahi@yahoo.com
Publication date & source: 2010, Eur J Cancer Care (Engl). , 19(3):308-12
To prepare and evaluate an allopurinol mouth rinse for prophylaxis of
fluorouracil-induced mucositis, 33 patients with malignant disorders, who were
going to receive 5-fluorouracil containing chemotherapy, were enrolled in a
placebo-controlled double-blinded randomized clinical trial. Allopurinol
mouthwash (1 mg/ml) or placebo was administered 1, 2 and 3 h after chemotherapy
and three consecutive nights. A questionnaire consisting of demographic
parameters, medical status, quality of life survey and mucosal injury scoring
table (based on World Health Organization scales for mucositis) was completed for
each patient at Day 1, 3 and 7 after chemotherapy. In allopurinol group nine
participants (60.0%) were female and in placebo group, 10 (66.7%) (P = 0.705).
Mean ages were 56.9 +/- 10.3 and 49.5 +/- 13.8 years in allopurinol and placebo
groups respectively (P = 0.107). The analysis showed that the higher education
level and the use of dentures significantly reduced the occurrence of mucositis,
and allopurinol mouth rinse (1 mg/ml) was ineffective in the prophylaxis of
fluorouracil-induced mucositis.
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