[Effects of lotensin and nitrendipine on plasma fibrinogen and platelet aggregation in hypertensive patients]

Author(s): Pan R, Sun M, Zhou H, Jia Z

Affiliation(s): Department of Medicine, Xiangya Hospital, Hunan Medical University, Changsha.

Publication date & source: 1998, Hunan Yi Ke Da Xue Xue Bao., 23(1):87-9.

Publication type: Clinical Trial; Randomized Controlled Trial

Plasma fibrinogen and platelet aggregation were measured by turbidimetric immunoassay, turbidimetry in 47 hypertensive patients and 20 normotensive control subjects. Among the 47 hypertensives, 24 cases were received lotensin and 23 nitrendipine. The plasma fibrinogen was increased and platelet aggregation enhanced in hypertensive patients before treatment. Platelet aggregation decreased after 8 weeks of treatment with lotensin or nitrendipine respectively. Lotensin decreased plasma fibrinogen whereas nitrendipine did not. It was concluded that both lotensin and nitrendipine decreased platelet aggregation; lotensin decreased plasma fibrinogen but nitrendipine did not.