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Coronary bifurcation lesions treated with simple approach (from the Cordoba & Las Palmas [CORPAL] Kiss Trial).

Author(s): Pan M, Medina A, Suarez de Lezo J, Romero M, Segura J, Martin P, Suarez de Lezo J, Hernandez E, Mazuelos F, Moreno A, Pavlovic D, Ojeda S, Toledano F, Leon C

Affiliation(s): Department of Cardiology, Reina Sofia Hospital, University of Cordoba, Instituto Maimonides para la Investigacion Biomedica de Cordoba (IMIBIC), Cordoba, Spain. manuelpan@telefonica.net

Publication date & source: 2011-05-15, Am J Cardiol., 107(10):1460-5. Epub 2011 Mar 15.

Publication type: Comparative Study; Randomized Controlled Trial

The present report compared the incidence of 1-year clinical events in patients with bifurcation lesions that had been treated with a simple approach who were randomized to either a simultaneous final kissing balloon (KB) or an isolated side-branch (SB) balloon post-dilation. From February 2007 to December 2008, 293 patients with all types of Medina bifurcation lesions were enrolled in a prospective study. All patients underwent implantation of a sirolimus- or everolimus-eluting stent across the bifurcation and provisional SB stenting. Patients with no SB ostial compromise or those needing a second stent were excluded from the present study (n = 49). The eligible patients were randomly assigned to treatment with final KB inflation (n = 124, KB group) or isolated balloon after dilation (n = 120, non-KB group). No significant differences were found between the patients from the KB and non-KB groups in terms of age, risk factors, clinical status, or location of the bifurcation lesions. The angiographic data and immediate results were also similar in both groups. Four patients experienced a non-Q-wave acute myocardial infarction in the hospital: three (2%) from the KB group and one (1%) from the non-KB group. Two in-hospital deaths occurred in the non-KB group. Target lesion revascularization was required in 7 patients (3%): 5 from the KB group and 2 from the non-KB group. Late mortality occurred in 3 patients from the KB group and 2 patients from the non-KB group. The incidence of major events at 1 year (death, target lesion revascularization, or acute myocardial infarction) was similar in both groups: 11 (9%) from the KB group and 7 (6%) from the non-KB group (p = NS). In conclusion, no differences in the clinical outcome at 1 year of follow-up were observed between the patients with bifurcation lesions treated with a simple approach and either a simultaneous final KB or an isolated SB balloon post-dilation. Copyright (c) 2011 Elsevier Inc. All rights reserved.

Page last updated: 2011-12-09

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