Pregabalin and gabapentin for post-photorefractive keratectomy pain: a randomized
Author(s): Pakravan M, Roshani M, Yazdani S, Faramazi A, Yaseri M.
Affiliation(s): Ophthalmic Research Center and Department of Ophthalmology, Labbafinejad Medical
Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran.
Publication date & source: 2012, Eur J Ophthalmol. , 22 Suppl 7:S106-13
PURPOSE: To evaluate the efficacy of pregabalin and gabapentin for reducing
post-photorefractive keratectomy (PRK) pain.
METHODS: In this randomized clinical trial, 150 subjects undergoing PRK were
allocated into 3 groups. In addition to the routine regimen, pregabalin 75 mg,
gabapentin 300 mg, and placebo were administered 3 times daily for 3 days, in
groups 1, 2, and 3, respectively. Subjects could take acetaminophen-codeine
300/10 mg tablets every 4 hours as needed. Patients completed a pain assessment
survey (visual analogue scale ranging from 0 = no pain to 10 = most severe pain)
7 times in the first 3 days following PRK and also recorded the number of
consumed acetaminophen-codeine tablets.
RESULTS: Age, sex, refractive error, ablation depth, and mitomycin-C (MMC)
application were similar in the 3 study groups (all p values>0.05). Overall pain
scores in the placebo group were 0.9 and 1 unit higher than the pregabalin
(p=0.029) and gabapentin (p=0.023) groups, respectively. Severe pain (score >7)
was more frequent in the placebo group on the morning of the first postoperative
day (p=0.043). The difference in the number of consumed acetaminophen-codeine
tablets was statistically borderline (p=0.061) and less in the pregabalin (7.9 ±
5.2) and gabapentin (9.0 ± 4.1) groups in comparison to the placebo group (10.3 ±
CONCLUSIONS: Pregabalin and gabapentin seem to be helpful in alleviating post-PRK
pain when combined with other measures. Depending on availability, either
compound can be used as an adjuvant for pain control in this setting.