Neuroleptic malignant syndrome induced by ziprasidone on the second day of treatment.

Author(s): Ozen ME, Yumru M, Savas HA, Cansel N, Herken H

Affiliation(s): Department of Psychiatry, Gaziantep University Faculty of Medicine, Gaziantep, Turkey.

Publication date & source: 2007, World J Biol Psychiatry., 8(1):42-4.

Publication type: Case Reports

Neuroleptic malignant syndrome (NMS) is the rarest and most serious of the neuroleptic-induced movement disorders. We describe a case of neuroleptic malignant syndrome (NMS) associated with the use of ziprasidone. Although conventional neuroleptics are more frequently associated with NMS, atypical antipsychotic drugs like ziprasidone may also be a cause. The patient is a 24-year-old male with a history of schizophrenia who developed signs and symptoms of NMS after 2 days of treatment with an 80-mg/day dose of orally administrated ziprasidone. This case is the earliest (second day of treatment) NMS due to ziprasidone reported in the literature.