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Valproic acid has no effect on pain in polyneuropathy: a randomized, controlled trial.

Author(s): Otto M, Bach FW, Jensen TS, Sindrup SH

Affiliation(s): Department of Neurology, Odense University Hospital, Denmark. maritotto@dadlnet.dk

Publication date & source: 2004-01-27, Neurology., 62(2):285-8.

Publication type: Clinical Trial; Randomized Controlled Trial

The aim of this randomized, double-blind, placebo-controlled cross-over study was to test whether valproic acid relieves painful polyneuropathy. Thirty-one patients completed two treatment phases of 4 weeks' duration with valproic acid (1,500 mg daily) and placebo. There was no significant difference between valproic acid and placebo in the rating of total pain (median, 5 in the valproic acid period vs 6 in the placebo period; p = 0.24) or in individual pain ratings.

Page last updated: 2006-01-11

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