DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Long-term immunity in young adults after a single dose of inactivated Hepatitis A vaccines.

Author(s): Orr N, Klement E, Gillis D, Sela T, Kayouf R, Derazne E, Grotto I, Balicer R, Huerta M, Aviram L, Ambar R, Epstein Y, Heled Y, Cohen D

Affiliation(s): Center for Vaccine Development and Evaluation, IDF, Israel. naorr@012.net.il

Publication date & source: 2006-05-15, Vaccine., 24(20):4328-32. Epub 2006 Mar 20.

Publication type: Randomized Controlled Trial

We evaluated in a prospective study the immune response of naive subjects to a single dose of inactivated Hepatitis A vaccine. Ninety-seven percent of the vaccinees sero-converted 1 month after vaccination and 93% were still positive 2 years later. All of the vaccinees had a strong booster response 2 years after the single dose. Avaxim was more immunogenic than Vaqta for the primary dose (p = 0.01 for sero-positivity, p<0.001 for antibody level) but no differences were found after boosting with Avaxim. Performance of intense physical activity during the first month after a single vaccine dose was associated with lower antibody levels (p = 0.004). This study indicates that a single dose of inactivated HAV vaccine elicits protective immune memory for at least 2 years.

Page last updated: 2006-11-04

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017