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Long-term outcomes in patients with schizophrenia treated with risperidone long-acting injection or oral antipsychotics in Spain: results from the electronic Schizophrenia Treatment Adherence Registry (e-STAR).

Author(s): Olivares JM, Rodriguez-Morales A, Diels J, Povey M, Jacobs A, Zhao Z, Lam A, Vega JC, Cuellar JA, de Castro FJ, Quintero CM, Martiin JF, Dominguez PT, Ojeda JL, Cortes SS, Cala FI, Marin CG, Castro LM, Duaso MA, Albarracin JR, Vergara GN, Benitez AF, Cleries FM, Perez-Brian JM, Aragon AB, Navarro JC, Biedma JA, de Pedro RB, Gonzalez JF, Lopez ME, Moreno HD, Lopez JA, Rodriguez EO, de Hoyos CM, Sacristan MP, Martin MD, Ballesteros EM, Rodriguez PA, Menendez LF, Rivas RS, del Pino Cuadrado P, Lauffer JC, Solano JJ, Martinez JM, Solano FG, Rodriguez PG, Rodriguez JA, Cano TR, Fortacin MD, Lobeiras JM, Sampedro JM, Bravo AP, Pellicer AF, Lopez MD, Liste JF, Fernandez MR, Losada AC, Mendez RV, Romero SA, Blanco JJ, Bonaselt IT, Mahia MC, del Valle EF, Yanez PQ, Camarasa MG, Alonso JA, Mendez GF, Feliz FD, Lamela MA, Pinero MV, Alvarado PF, Gomez IL, Martin PF, Gomez JL, Lopez AG, Jimenez AR, Nafs AE, Barquero NC, Ortiz RF, Noguera JL, Carrasco PR, Munoz JM, Palma MM, Hortelano CM, Bonome LS, Sevilla JS, Juan JM, Ramos JM, Munoz JL, Guisasola JE, Vazquez LS, Guerras FC, Nebot FJ, Fernandez FJ, Nicolau AL, Subirats RC, Kidias MM, Navarro VF, Garcia BF, del Rosal FM, de Vicente Munoz T, Ballester JA, Lieb PM, Martel AD, Bea ER, Joaquim IG, Enjuanes FB, Pinol MB, Carbonell EF, Munoz RM, Giribets CA, Sans LA, Blanco AS, Felipe MA, Munoz PG, Villanueva AP, Arroyo MB, Borri RC, Fallada SM, Merola MC, Rodon EP, Palmes JR, Martinez EP, Catala JM, Coca AS, Ferrandiz FP, Paya EF, Caballero GI, Bonet AF, Figueras JF, Pagador PM, Garibo MM, Camo VP, Carrillo CS, Valero CP, Rebollo FJ, Campayo JG, Sala Ayma JM, Roig MM, de Una Mateos MA, Bertolin RG, Garcia AM, Mazo FJ, Velasco JL, Perez LS, Casado CJ, Barba JJ, Diaz MC, Rubio JP, Mandoli AS, Herrero AU, Martinez AR, Serrano PS, Rodriguez EN, Montesinos JS, Macia JF, Mateos Marcos AM, Soto JV, Dumont MV, Pagan JP, Martinez VB, Santiuste de Pablos M, Delgado CE, Quiles MD, Lopez FJ, Navarro PP, Torres AM, Ingles FJ, Arias-Camison JM, Manzano JC, Pena RV, Guitarte GP, Fontecilla HB, Romero JB, Gil RS, Lozano JM, Adanez LD, Zarranz Herrera-Oria I, Jimenez JP, Vaz FC, Garcia OS, Anton CC, Casula RR, Hernandez MC, Escabias FT, Torresano JR, Perez-Villamil AH, Estevez L, Figuero MA, Munoz de Morales A, Calvin JL, Criado MD, Rodriguez VM, Ambrosolio EB, Madera PM, Alfaro GP, Vidal MM, Valtuille AG, Ruiz O, Cabornero GL, Echevarria Martinez de Bujo M, Mallen MJ, Puigros JS, Martorell AL, Forteza AC, Arrebola ER, Rodriguez de la Torre M, Saiz CG, Bardolet I Casas C, Linde ER, De Arce Cordon R, Molina EM, Carazo FJ, Romero JJ, Cano DV, Dorado MS, Velazquez SC, Sanchez AJ, Leon SO, Sanchez KP, Benitez MH, Zugarramurai AI, Contreras MA, De la Varga Gonzalez M, Marin PB, Robina FG, Garcia MS, Perez FJ, Bros PC, Gomez AC, de Dios Molina Martin J, Perera JL, Averbach MC, Perera JL, Palancares EG, Gallego de Dios MT, Rojo CF, Iglesias SS, Merino MI, Mestre NP, Urdaniz AP, Sanchez JM, Seco RG, Munoz JF, Agut MM, Lozano ML, Herguedas FM, Pena AT, Garcia JV, Martinez AV, Sanz Granado OS, Fernandez MA, Canseco JM, Lopez PA, Martin MA, Barrio JA, Ubago JG, Bennassar MR, Diez JM, Fleta JL, Fortes FP, Lopez CA, Medina O, Alvarez DF, Roca JM, Valladolid GR, Tavera JA, Garcia-Castrillon Sales JA, Llordes IB, Melgarejo CA, Canas de la Paz F, Callol VV, Garcia MB, Garcia JB, Leal FJ, Corrales EC, Iglesias ES, Gomez MA, Serrano GG, Chillaron EG, Aguado FJ, Castillo JJ, Gonzalez AG, Vazquez JG, Peralvarez MB, Diaz MR, Mesa MY, Artiles FJ, Chao MA, Mesa MY, del Rosario Santana P, Escudero MA, Berenguer MM, Llacer JM, Berna JA, Ortiz JB, Pardell LT, Hernandez-Alvarez de Sotomayor C, Mendez MR, Garate RC, Mugica BD, Gonzalez MC, Domingo JP, Navarro CS, Vera GS, Cuquerella MA, Monzo JL, Boada PC, Perez MF, Parrado EC, Sanchez JJ, Fernandez JC, e-STAR Spanish Study Group

Affiliation(s): Department of Psychiatry, Hospital Meixoeiro, Complejo Hospitalario Universitario de Vigo, Vigo Spain. jose.manuel.olivares@gmail.com

Publication date & source: 2009-06, Eur Psychiatry., 24(5):287-96. Epub 2009 Feb 4.

Publication type: Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

BACKGROUND: The electronic Schizophrenia Treatment Adherence Registry (e-STAR) is a prospective, observational study of patients with schizophrenia designed to evaluate long-term treatment outcomes in routine clinical practice. METHODS: Parameters were assessed at baseline and at 3 month intervals for 2 years in patients initiated on risperidone long-acting injection (RLAI) (n=1345) or a new oral antipsychotic (AP) (n=277; 35.7% and 36.5% on risperidone and olanzapine, respectively) in Spain. Hospitalization prior to therapy was assessed by a retrospective chart review. RESULTS: At 24 months, treatment retention (81.8% for RLAI versus 63.4% for oral APs, p<0.0001) and reduction in Clinical Global Impression Severity scores (-1.14 for RLAI versus -0.94 for APs, p=0.0165) were significantly higher with RLAI. Compared to the pre-switch period, RLAI patients had greater reductions in the number (reduction of 0.37 stays per patient versus 0.2, p<0.05) and days (18.74 versus 13.02, p<0.01) of hospitalizations at 24 months than oral AP patients. CONCLUSIONS: This 2 year, prospective, observational study showed that, compared to oral antipsychotics, RLAI was associated with better treatment retention, greater improvement in clinical symptoms and functioning, and greater reduction in hospital stays and days in hospital in patients with schizophrenia. Improved treatment adherence, increased efficacy and reduced hospitalization with RLAI offer the opportunity of substantial therapeutic improvement in schizophrenia.

Page last updated: 2009-10-20

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