[Efficacy evaluation of lafutidine for mild reflux esophagitis in Japanese
patients]. [Article in Japanese]
Author(s): Ohara S, Haruma K, Kinoshita Y, Kusano M.
Affiliation(s): Department of Gastroenterology, Tohoku Rosai Hospital, Japan.
sohara1122@tohokuh.rofuku.go.jp
Publication date & source: 2010, Nihon Shokakibyo Gakkai Zasshi. , 107(4):588-97
To evaluate the efficacy of lafutidine (20mg) , famotidine (40mg) and placebo in
patients with mild reflux esophagitis (Grades A and B according to the Los
Angeles classification) , a double-blind, multicenter, randomized clinical trial
was performed for the first time in Japanese patients. In addition to each
physician's evaluation, efficacy was evaluated by judging panels using images
submitted by each physician. The healing rate after 8 weeks for lafutidine,
famotidine and placebo were 67.7%, 56.6% and 41.2%, respectively. Lafutidine was
significantly more effective than placebo (p=0.002, according to the judging
panels) . Based on the evaluation of endoscopic images by the judging panels, 91
(27.1%) of 336 images submitted by each physician were judged to not be mucosal
breaks. Judging panels are considered one of the ways to resolve the problem of
the need to unify the criteria.
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