Randomized, controlled trial efficacy of pneumococcal conjugate vaccine against otitis media among navajo and white mountain apache infants.

Author(s): O'Brien KL, David AB, Chandran A, Moulton LH, Reid R, Weatherholtz R, Santosham M

Affiliation(s): From the Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Publication date & source: 2008-01, Pediatr Infect Dis J., 27(1):71-3.

Publication type:

We report the phase III trial efficacy of 7-valent pneumococcal conjugate vaccine against clinical and culture proven otitis media (OM) among Navajo and White Mountain Apache infants. Efficacy was -0.4% (95% CI: -19.4 to 15.6) for clinically-diagnosed OM, 5.1% (95% CI: -51.5 to 40.6) for severe OM, and 64% (95% CI: -34% to 90%) for vaccine serotype pneumococcal OM suggesting that this vaccine is efficacious for pneumococcal OM in this high risk population.