Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria.

Author(s): Newton PN, Chaulet JF, Brockman A, Chierakul W, Dondorp A, Ruangveerayuth R, Looareesuwan S, Mounier C, White NJ

Affiliation(s): Mae Sot, Tak and Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand.

Publication date & source: 2005-04, Antimicrob Agents Chemother., 49(4):1622-5.

Publication type: Clinical Trial; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal.