Melancholic symptoms during concurrent olanzapine and fluoxetine.
Author(s): Nelson LA, Swartz CM
Affiliation(s): St. Louis University School of Medicine, Department of Psychiatry, Missouri 63104, USA. lnelson@stlcop.edu
Publication date & source: 2000-09, Ann Clin Psychiatry., 12(3):167-70.
Publication type: Case Reports
The concomitant use of olanzapine and fluoxetine has been advocated for the treatment of various psychiatric disease states. We describe a case in which the combination of olanzapine and fluoxetine appears to have caused the psychopathology of melancholic depression requiring hospitalization in a 40-year-old female. Postulated mechanisms for this drug interaction, particularly CYP450 isoenzyme inhibition by fluoxetine, is discussed.
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