Does corticosteroid have any beneficial effect on voice change after
thyroidectomy?
Author(s): Nasiri S(1), Shafag S, Khorgami Z, Sodagari N, Aminian A, Hedayat A.
Affiliation(s): Author information:
(1)Department of General Surgery, Tehran University of Medical Sciences, Tehran,
Iran.
Publication date & source: 2013, Am Surg. , 79(12):1258-62
Voice alteration is one of the most common complications after thyroidectomy. It
has a serious effect on social communication and economic and psychosocial status
of patients. It has been hypothesized that inflammation and edema in the surgery
site has a major role in voice change after thyroidectomy. This randomized
clinical trial study was design to evaluate the effect of a single preoperative
dose of steroid on voice change after thyroidectomy. This is a prospective
randomized clinical trial with registration no. IRCT201106306925N. From all
definitive candidates for total thyroidectomy, eligible patients were selected
after exclusion of 12 criteria. Selected cases were randomly allocated to two
groups. One group received intravenous dexamethasone preoperatively. Other group
received placebo. Voice change was evaluated by Voice Impairment Score (VIS)
postoperatively. Sixty-four patients were entered in the study and divided into
two groups (dexamethasone and placebo). VIS was significantly different at the
first day after surgery between dexamethasone (five) and controls (13; P <
0.001). This difference was seen after 7 days but without statistically
significance (one vs three; P = 0.397). VIS score significantly decreased on the
seventh day related to the first day (P < 0.001) in both groups. There were no
significant dexamethasone complications in either group. Preoperative
dexamethasone may decrease voice change after thyroidectomy.
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