Comparison of Avena Sativa, Vinegar, and Hydroxyzine for Uremic Pruritus of
Hemodialysis Patients: a Crossover Randomized Clinical Trial.
Author(s): Nakhaee S, Nasiri A(1), Waghei Y, Morshedi J.
Affiliation(s): Author information:
(1)Health Qualitative Research Center, Birjand University of Medical Sciences,
Birjand, Iran. nasiri2006@bums.ac.ir.
Publication date & source: 2015, Iran J Kidney Dis. , 9(4):316-22
INTRODUCTION: Uremic pruritus is a common complication in patients with chronic
kidney disease. While its cause is not known for certain, different treatments
are currently applied. This study aimed to compare the effects of Avena sativa,
diluted vinegar, and hydroxyzine on the reduction of uremic pruritus.
MATERIALS AND METHODS: In this crossover randomized clinical trial, 23
hemodialysis patients with uremic pruritus were randomly divided into 3 groups.
The first group was treated with Avena sativa lotion, twice a day, for as long as
2 weeks; the second group received diluted vinegar; and the third group took
hydroxyzine tablets for the same time span. After 3-day-long washout periods, the
therapeutic methods were crossed over. The data were collected by a pruritus
scale and a visual analogue scale, which were completed before and after the
interventions.
RESULTS: Avena sativa lotion significantly decreased the mean scores of pruritus
intensity, consequences, and the verbal descriptor, although it did not have a
significant effect on the frequency of pruritus and the pruritic surface. Vinegar
and hydroxyzine significantly decreased all of the scores. Conclusions. Avena
sativa, vinegar, and hydroxyzine were effective in decreasing pruritus. Diluted
vinegar and Avena sativa can be used as a complement to hydroxyzine, which is
itself a common pharmaceutical therapy.
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