Fournier's gangrene and scrotal ulcerations during all-trans-retinoic acid therapy for acute promyelocytic leukemia.

Author(s): Naithani R, Kumar R, Mahapatra M

Affiliation(s): Department of Hematology, All India Institute of Medical Sciences, New Delhi, India. dr_rahul6@hotmail.com

Publication date & source: 2008-08, Pediatr Blood Cancer., 51(2):303-4.

Publication type: Case Reports

Scrotal ulcers are a rare manifestation in patients with acute promyelocytic leukemia. Fournier's gangrene (FG) is even rarer. We describe three adolescents and young adults who developed scrotal ulcerations during induction with all-trans-retinoic acid. One patient developed FG. These lesions are predominantly seen in Asian population. A good outcome with supportive management occurred in all the cases.